Technologies and know-how
Aseptic primary packaging
Aseptic fill/finish
Maximum product safety for complex drug products
Aseptic fill/finish is a key success factor in the manufacture of sterile drug products and biologics. Primary packaging plays a decisive role in ensuring sterility, product protection and compliance with regulatory requirements. In the pharmaceutical, biotech and 503B compounding sectors, this process step is critical for sterility assurance, product integrity and regulatory safety.
Harro develops aseptic solutions that enable reliable process control and protect the active ingredient from contamination throughout the fill/finish process. The precision technologies are tailored to the specific requirements of sterile and biological products, enabling manufacturers to implement even challenging applications in a process‑reliable, GMP‑compliant manner.
Harro’s primary packaging solutions include applications in the following fields:
Cell and gene therapies
Lipid‑nanoparticle‑based formulations
Implantable drug products
Novel injection and drug‑delivery concepts
Further sterile drug products and biologics
Industries and applications
Liquid filling of bags in a sterile environment.
Automated handling and aseptic filling of IV bags.
Liquid filling of diagnostic products under aseptic conditions.
Perfectly aligned system solutions
Focus on your product
The design of Harro’s aseptic fill/finish solutions is consistently aligned with the product and its specific process requirements. In close cooperation with customers, Harro develops and implements aseptic processes from laboratory scale through to commercial production.
This is based on state‑of‑the‑art aseptic fill/finish technologies, a customer‑specific design approach and the use of proven, modular components. In addition, tailored services cover all phases of the project lifecycle.
Bags
Bags may look simple, but their aseptic filling and packaging processes are complex. With our aligned technologies, we prevent contamination and reliably protect your product – from no-touch transfer through to sealing.
Packaging types
Harro is one of the leading providers of precise, aseptic filling and dosing solutions for challenging liquids and powders. The solutions are designed for a wide range of primary containers and meet the highest requirements in terms of process reliability and dosing accuracy.
Supported container types include, among others:
Vials
Single‑ and multi‑chamber syringes
Bottles
Single‑ and multi‑chamber bags
Projects and innovations with Harro Höfliger
Successful projects
Medical Technologies
Gentle handling of lyo bead pellets
For the handling of lyophilisates, Harro Höfliger offers a unique automated solution – the Lyo Bead Dispenser. The freeze-dried pellets are safely conveyed and accurately dosed via air flow.
Pharmaceutical Technologies
High-performance production of a special capsule solution
With the Accordion Pill®, Intec Pharma has developed an innovative capsule platform that provides continuous drug release. The manufacturing technology for the product was supplied by Harro Höfliger.
Pharmaceutical Technologies
Sterile filling of infusion bags
New B Innovation Limited (New β Innovation) uses a partially automated aseptic filling and sealing line for pre-sterilized infusion bags.
Pharmaceutical Technologies
Re-usable Inhaler Respimat®
Since 2004, the Respimat® has been ensuring easy inhalation for patients with diseases such as asthma and COPD. In 2019, Boehringer Ingelheim launched the re-usable version of this inhaler.