Technologies and know-how
Barrier technology
Optimally combining protection and operability
Handling highly potent substances in filling and packaging processes requires special protection for both people and the environment. At the same time, foreign substances must be kept away from the product, and production processes – from setup to cleaning – must be designed to be simple and efficient. With sophisticated aseptic and containment technology, as well as expertise in OELs (occupational exposure limits) below 0.05 µg/m³, we ensure that all criteria are met. Depending on the application and OEL requirements, we implement the appropriate cGMP-compliant systems. The spectrum ranges from controlled extraction solutions to open and closed barrier systems – oRABS and cRABS – through to isolators. Everything is manufactured in-house with the best possible combination of operability and barrier effectiveness.
Our expertise
Protected and easy access to the process via integrated glove ports.
Filling capsules in a containment system on a machine with hygienic design – with an easy-to-clean structure for production under sterile conditions.
Automated handling and aseptic filling of IV bags.
Wash-in-Place technology (WiP) for safely cleaning the interior of a capsule filling machine with containment.
Capsule filling machine with containment for safely protecting the product, operating personnel, and the environment.
Fast product changeover even under containment conditions: The dosing stations on the rotary table of the capsule filling machine can be easily exchanged thanks to the patented trolley principle.
Perfectly aligned system solutions
In focus: Your product
Highly potent powders in capsules, blister strips or disks for dry powder inhalers, complex infusion products for therapies with cell and gene-based APIs, multi-component packaging of liquids and powders. Your product defines the process. We bring over 30 years of experience to bear in aseptic production systems and align your barrier system exactly to the machine process. In development, our Consulting Services team supports you with your control contamination strategy, project planning, configuration, and the design of technical solutions, to name just a few areas.
IV Bags
IV bags may look simple, but their aseptic filling and packaging processes are complex. With our aligned technologies, we prevent contamination and reliably protect your product – from no-touch transfer through to sealing.
Projects and innovations with Harro Höfliger
