Innovative filling of metered dose inhalers
MDI Filling
MDI market in transition
The MDI market is undergoing significant change. New propellants are reshaping safety requirements and production concepts. Demand for flexibility, scalability, and economic efficiency is increasing across the entire product lifecycle.
Established filling technologies continue to form the basis for the production of numerous MDIs worldwide. Depending on the formulation and production requirements, different process approaches are used.
At the same time, emerging technologies create additional opportunities to address challenges related to propellant handling, production concepts and manufacturing flexibility. Therefore, Harro Höfliger, together with Pharmatec Solutions Ltd., has developed a new process approach for the next generation of MDI filling: Dry‑Filling.
Established processes
Conventional technologies such as Single‑Stage Pressure Filling, Two‑Stage Filling and Dual-Filling are widely used in the commercial production of MDIs. For these processes, Harro Höfliger offers suitable development, testing and production solutions throughout the entire product lifecycle.
Innovative: Decoupled handling of powder and propellant
The Dry-Filling process
Key benefits
From lab to production
Dry‑Filling is already available at lab scale today. This enables systematic evaluation of formulations and process parameters, with data forming a solid basis for further scale‑up.
Get in touch
Interested in MDI Filling? Let’s talk.
More information
Aerodynamic performance of MDIs from alternative processes
An assessment of the effects of vacuum crimping
Assessing bench‑scale dry powder filling for MDIs
Budesonide micronization and suspension effects in propellants
Innovative filling process for metered dose inhalers
Reducing HFA‑152a risks with decoupled filling
